The sweet spot for the optimal mpg on the 6.2 is at 55 mph. The same would probably be said about the 5.3 mounted to a 10-speed. With that said, the best I've seen on my 2020 Trail Boss LT with the 6.2 is 24.4 with the cruise control set at 78 mph. That was with the stock 275/65r18 Goodyear Wrangler Duratracs. The ZR2 and AT4X have larger tires, so you'll see lower mpg than I did. With that said, I'm currently running 285/75r18 Goodyear Wrangler Duratracs and the decrease in mpg is ~2-3mpg. The greatest decrease is at freeway speed.
If you're concern is truly about mpg I recommend looking into the 3.0 Duramax diesel engine. It produces more torque than the 6.2 and almost as much horsepower as the 5.3. Since the 6.2 recommends premium fuel, and diesel sells for about the same price as premium, thus might be the more optimal direction for you to go.
Other areas to pay attention to are valve springs on the V8 engines, sliding rear window, and torque converter on the 10-speed.